UMD

You are invited to join us for a special event at Public Health Research@Maryland 2015 hosted by Agilent Technologies. The event will include two exciting speakers and presentations:

Date: April 9, 2015
Public Health Research@Maryland 2015

Room: Nanticoke Room

Time: 11:30am - 12:30pm
Lunch Provided

Title: The connectivity approach to the exposome: causal health and environment-wide associations
Speaker:
Denis Sarigiannis, Associate Professor of Environmental Engineering, Department of Chemical Engineering
Aristotle University of Thessaloniki, Greece and Institute of Advanced Study, Pavia, Italy


Environmental health and exposure sciences are moving away from single point bottom-up approaches of measuring one exposure and one effect to a high dimension discovery approach using multi-omics and multi-sensor data. The exposome paradigm incorporates non-targeted techniques to create putative hypotheses on adverse outcome pathways and identify relevant biomarkers, followed by a targeted approach to differentiate biomarkers of exposure and disease and identify the most plausible mechanisms underlying the exposure-to-effect continuum.
Prof Sarigiannis will talk about the integration of genome and exposome-wide interaction studies, combining existing cohort data and a new longitudinal and nested case-control study, including twins and singletons, and their mothers and fathers. Detailed exposure data, gathered from exposure sensors, biological and environmental monitoring, will be key to refining exposure models that capture lifetime exposures, from preconception through later life. Endogenous exposures are studied using a full array of molecular pathways, with a focus on DNA methylation. The high dimension exposure biology data are processed using big data analytics and biology-inspired modeling to explore causation in the environment and health associations.
 

Title:Exposomic Analyses for Chemical, Biochemical and Epigenetic Differences in Children with Autism and Control Children in a Double-blind Study Evaluating New Methods Assessment
Speaker:
H.M. (Skip) Kingston, Ph.D., Professor, Duquesne University, Dept. of Chemistry and Biochemistry, Pittsburgh, PA

Exposomics is a relatively new recognized branch of science with an environmental human health focus based on realization that non-communicable diseases are caused by toxins in the environment, resulting in epigenetic changes and metabolic alterations in the human body. In a recent four-year study, over twenty unique personal chemistry indicators that are statistically significant at the 95% Confidence Interval have been determined in children with autism as compared to control children. The study was a clinical research trial of children with Autism compared to control children who were age, sex and socioeconomically matched within a one hour radius of Pittsburgh, Pennsylvania, USA.  The experiments required over 300,000 individual biometric measurements of organic toxins, metals and elements, and two unique biomarker and epigenetic assays.  New Direct Isotope Dilution and Speciated Isotope Dilution methods (D-IDMS and D-SIDMS) adopted by the United States Environmental Protection Agency (EPA) were optimized and applied. These methods are known as the EPA Method 6800, Update V, approved in 2013. The experimental protocol was designed with many goals and specific aims, including improvements or creation of advanced measurements to assist in differentiating the chemistry of the children as early as possible. We have published two categories of papers; first, the method papers as we were forced to invent and develop new methods to accomplish these Exposomic assessments and second, the medical findings of these 300,000 measurements statistically evaluated.  We have found that our cohort of children with autism is statistically distinct chemically when compared to our control cohort. These results will be reviewed and discussed.  This chemical differentiation may eventually lead to risk assessment and diagnosis of autism before symptoms and brain damage appear.  

Register today to ensure a seat!

 
Online Registration closed on Friday, April 10, 2015.